Some of the tips are a bit specific to bioinformatics / computer science, but one idea I really liked was to have a chronologically-organised electronic notebook for each project. This would sketch out analyses / experiments you tried, what worked, and what didn’t. You could also “transcribe notes from conversations as well as email text into the lab notebook”. This type of document makes way more sense to me than keeping a single general lab notebook for all the projects you’re doing. Perhaps that helps you too, but notes about a specific project should all be accessible within the project directory. This idea would definitely complement some others that I’ve previously detailed on this blog.